Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P
- Авторы: Ussov W.1, Belyanin M.1, Bezlepkin A.1, Borodin O.1, Bobrikova E.1, Shimanovskii N.2
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Учреждения:
- Research Institute of Cardiology
- N. I. Pirogov Russian Research Medical University
- Выпуск: Том 161, № 5 (2016)
- Страницы: 715-718
- Раздел: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/237706
- DOI: https://doi.org/10.1007/s10517-016-3492-1
- ID: 237706
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Аннотация
Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N’,N’-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.19±0.11 for the central areas and 1.47±0.17 for the peripheral ones. The pituitary (1.18±0.05) and vascular plexuses of the lateral ventricles (1.12±0.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.
Об авторах
W. Ussov
Research Institute of Cardiology
Email: mritomsk@yandex.ru
Россия, Tomsk
M. Belyanin
Research Institute of Cardiology
Email: mritomsk@yandex.ru
Россия, Tomsk
A. Bezlepkin
Research Institute of Cardiology
Email: mritomsk@yandex.ru
Россия, Tomsk
O. Borodin
Research Institute of Cardiology
Email: mritomsk@yandex.ru
Россия, Tomsk
E. Bobrikova
Research Institute of Cardiology
Email: mritomsk@yandex.ru
Россия, Tomsk
N. Shimanovskii
N. I. Pirogov Russian Research Medical University
Автор, ответственный за переписку.
Email: mritomsk@yandex.ru
Россия, Moscow