Dihydroquercetin Does Not Affect Age-Dependent Increase in Blood Pressure and Angiotensin-Converting Enzyme Activity in the Aorta of Hypertensive Rats
- 作者: Slashcheva G.1, Rykov V.1, Lobanov A.1, Murashev A.1, Kim Y.2, Arutyunyan T.3, Korystova A.3, Kublik L.3, Levitman M.3, Shaposhnikona V.3, Korystov Y.3
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隶属关系:
- Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institute of Cell Biophysics, Russian Academy of Sciences
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- 期: 卷 161, 编号 5 (2016)
- 页面: 670-673
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/237660
- DOI: https://doi.org/10.1007/s10517-016-3482-3
- ID: 237660
如何引用文章
详细
We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme. Thus, the early (7-14 weeks) increase in BP and angiotensin-converting enzyme activity in the aorta of SHR rats was not modified by flavonoids (dihydroquercetin) in contrast to other rat strains and humans, which is indicative of specificity of hypertension mechanism in SHR rats.
作者简介
G. Slashcheva
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
V. Rykov
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
A. Lobanov
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
A. Murashev
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
Yu. Kim
Institute of Cell Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
T. Arutyunyan
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
V. Shaposhnikona
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino