Dihydroquercetin Does Not Affect Age-Dependent Increase in Blood Pressure and Angiotensin-Converting Enzyme Activity in the Aorta of Hypertensive Rats
- Авторлар: Slashcheva G.1, Rykov V.1, Lobanov A.1, Murashev A.1, Kim Y.2, Arutyunyan T.3, Korystova A.3, Kublik L.3, Levitman M.3, Shaposhnikona V.3, Korystov Y.3
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Мекемелер:
- Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institute of Cell Biophysics, Russian Academy of Sciences
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Шығарылым: Том 161, № 5 (2016)
- Беттер: 670-673
- Бөлім: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/237660
- DOI: https://doi.org/10.1007/s10517-016-3482-3
- ID: 237660
Дәйексөз келтіру
Аннотация
We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme. Thus, the early (7-14 weeks) increase in BP and angiotensin-converting enzyme activity in the aorta of SHR rats was not modified by flavonoids (dihydroquercetin) in contrast to other rat strains and humans, which is indicative of specificity of hypertension mechanism in SHR rats.
Авторлар туралы
G. Slashcheva
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
V. Rykov
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
A. Lobanov
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
A. Murashev
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
Yu. Kim
Institute of Cell Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
T. Arutyunyan
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
V. Shaposhnikona
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Ресей, Pushchino
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: ykorystov@rambler.ru
Ресей, Pushchino