Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus
- 作者: Pirogov A.1, Prikhod’ko A.1, Perelman Y.1, Zinovyev S.2, Afanasyeva E.1, Kolosov V.1
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隶属关系:
- Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
- Amur State Medical Academy
- 期: 卷 161, 编号 4 (2016)
- 页面: 550-553
- 栏目: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/237588
- DOI: https://doi.org/10.1007/s10517-016-3458-3
- ID: 237588
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详细
Positive reaction of the bronchi to distilled water inhalation in asthmatics is associated with significant stimulation of the respiratory epithelium desquamation against the background of increased content of eosinophilic and neutrophilic leukocytes in induced sputum, predomination of eosinophil and neutrophil cytolysis, and lower activity of myeloperoxidase in leukocyte granules (in comparison with the parameter in patients with a negative response to bronchostimulation). Enhanced cytolysis and destruction of leukocytes and high myeloperoxidase concentration in the extracellular space are essential for the development of bronchial hyperresponsiveness to hypoosmotic stimulus in asthma.
作者简介
A. Pirogov
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
俄罗斯联邦, Blagoveshchensk
A. Prikhod’ko
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
俄罗斯联邦, Blagoveshchensk
Yu. Perelman
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
编辑信件的主要联系方式.
Email: jperelman@mail.ru
俄罗斯联邦, Blagoveshchensk
S. Zinovyev
Amur State Medical Academy
Email: jperelman@mail.ru
俄罗斯联邦, Blagoveshchensk
E. Afanasyeva
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
俄罗斯联邦, Blagoveshchensk
V. Kolosov
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
俄罗斯联邦, Blagoveshchensk