Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus
- Authors: Pirogov A.B.1, Prikhod’ko A.G.1, Perelman Y.M.1, Zinovyev S.V.2, Afanasyeva E.Y.1, Kolosov V.P.1
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Affiliations:
- Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
- Amur State Medical Academy
- Issue: Vol 161, No 4 (2016)
- Pages: 550-553
- Section: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/237588
- DOI: https://doi.org/10.1007/s10517-016-3458-3
- ID: 237588
Cite item
Abstract
Positive reaction of the bronchi to distilled water inhalation in asthmatics is associated with significant stimulation of the respiratory epithelium desquamation against the background of increased content of eosinophilic and neutrophilic leukocytes in induced sputum, predomination of eosinophil and neutrophil cytolysis, and lower activity of myeloperoxidase in leukocyte granules (in comparison with the parameter in patients with a negative response to bronchostimulation). Enhanced cytolysis and destruction of leukocytes and high myeloperoxidase concentration in the extracellular space are essential for the development of bronchial hyperresponsiveness to hypoosmotic stimulus in asthma.
About the authors
A. B. Pirogov
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
Russian Federation, Blagoveshchensk
A. G. Prikhod’ko
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
Russian Federation, Blagoveshchensk
Yu. M. Perelman
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Author for correspondence.
Email: jperelman@mail.ru
Russian Federation, Blagoveshchensk
S. V. Zinovyev
Amur State Medical Academy
Email: jperelman@mail.ru
Russian Federation, Blagoveshchensk
E. Yu. Afanasyeva
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
Russian Federation, Blagoveshchensk
V. P. Kolosov
Laboratory of Functional Methods of Studies of the Respiratory System, Far Eastern Center of Respiratory Physiology and Pathology
Email: jperelman@mail.ru
Russian Federation, Blagoveshchensk