Angiogenic Effects of Dimeric Dipeptide Mimetic of Loop 4 of Nerve Growth Factor
- 作者: Kryzhanovskii S.1, Antipova T.1, Tsorin I.1, Pekeldina E.1, Stolyaruk V.1, Nikolaev S.1, Sorokina A.1, Gudasheva T.1, Seredenin S.1
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隶属关系:
- V. V. Zakusov Institute of Pharmacology
- 期: 卷 161, 编号 4 (2016)
- 页面: 513-517
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237553
- DOI: https://doi.org/10.1007/s10517-016-3450-y
- ID: 237553
如何引用文章
详细
Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic activity was not inferior to the reference neurotrophin NGF. In experiments with hindlimb ischemia modeled in rats, GK-2 (1 mg/kg intraperitoneally for 14 days) significantly increased the total length of capillary vessels (p<0.003) and the number of vessels per 1 mm2 ischemic tissue (p<0.001) in comparison with the control. Our findings indicate that under experimental conditions compound GK-2 exhibits not only angiogenic, but also anti-ischemic activity.
作者简介
S. Kryzhanovskii
V. V. Zakusov Institute of Pharmacology
编辑信件的主要联系方式.
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
T. Antipova
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
I. Tsorin
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
E. Pekeldina
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
V. Stolyaruk
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
S. Nikolaev
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
A. Sorokina
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
T. Gudasheva
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow
S. Seredenin
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
俄罗斯联邦, Moscow