Angiogenic Effects of Dimeric Dipeptide Mimetic of Loop 4 of Nerve Growth Factor
- Authors: Kryzhanovskii S.A.1, Antipova T.A.1, Tsorin I.B.1, Pekeldina E.S.1, Stolyaruk V.N.1, Nikolaev S.V.1, Sorokina A.V.1, Gudasheva T.A.1, Seredenin S.B.1
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Affiliations:
- V. V. Zakusov Institute of Pharmacology
- Issue: Vol 161, No 4 (2016)
- Pages: 513-517
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237553
- DOI: https://doi.org/10.1007/s10517-016-3450-y
- ID: 237553
Cite item
Abstract
Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic activity was not inferior to the reference neurotrophin NGF. In experiments with hindlimb ischemia modeled in rats, GK-2 (1 mg/kg intraperitoneally for 14 days) significantly increased the total length of capillary vessels (p<0.003) and the number of vessels per 1 mm2 ischemic tissue (p<0.001) in comparison with the control. Our findings indicate that under experimental conditions compound GK-2 exhibits not only angiogenic, but also anti-ischemic activity.
About the authors
S. A. Kryzhanovskii
V. V. Zakusov Institute of Pharmacology
Author for correspondence.
Email: sak-538@yandex.ru
Russian Federation, Moscow
T. A. Antipova
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
I. B. Tsorin
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
E. S. Pekeldina
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
V. N. Stolyaruk
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
S. V. Nikolaev
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
A. V. Sorokina
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
T. A. Gudasheva
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow
S. B. Seredenin
V. V. Zakusov Institute of Pharmacology
Email: sak-538@yandex.ru
Russian Federation, Moscow