Effect of Prolyl-Glycyl-Proline (PGP) and Its Acetylated Form (N-AcPGP) on Calcium Level in the Cytoplasm of Rat Peritoneal Mast Cells
- 作者: Bondarenko N.1, Kurenkova A.2, Nikishin D.1,2, Umarova B.2
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隶属关系:
- N. K. Koltsov Institute of Developmental Biology of the Russian Academy of Sciences
- M. V. Lomonosov Moscow State University
- 期: 卷 161, 编号 4 (2016)
- 页面: 487-490
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/237532
- DOI: https://doi.org/10.1007/s10517-016-3444-9
- ID: 237532
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详细
Tripeptide glycyl-prolyl-proline (PGP), a regulatory peptide of the glyproline family, possesses a pronounced anti-inflammatory effect primarily due to its ability to prevent secretion of the proinflammatory mediator histamine by rat peritoneal mast cells. Activation of mast cell with synacthen (ACTH1-24) and substance 48/80 leads to an increase in intracellular calcium concentration. Pretreatment of mast cells with PGP prevented calcium entry into the cytoplasm from both intercellular space and intracellular stores. Acetylated peptide (N-AcPGP) produced a similar effect on histamine release and intracellular calcium content in mast cells activated with synacthen. These findings indicate that both forms of the peptide can stabilize mast cells and prevent intracellular calcium increase.
作者简介
N. Bondarenko
N. K. Koltsov Institute of Developmental Biology of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: n.s.bondarenko@gmail.com
俄罗斯联邦, Moscow
A. Kurenkova
M. V. Lomonosov Moscow State University
Email: n.s.bondarenko@gmail.com
俄罗斯联邦, Moscow
D. Nikishin
N. K. Koltsov Institute of Developmental Biology of the Russian Academy of Sciences; M. V. Lomonosov Moscow State University
Email: n.s.bondarenko@gmail.com
俄罗斯联邦, Moscow; Moscow
B. Umarova
M. V. Lomonosov Moscow State University
Email: n.s.bondarenko@gmail.com
俄罗斯联邦, Moscow