Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide
- 作者: Gorbacheva A.1, Berdalin A.1, Stulova A.1, Nikogosova A.1, Lin M.1, Buravkov S.1, Gavrilova S.1, Koshelev V.1
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隶属关系:
- Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
- 期: 卷 161, 编号 4 (2016)
- 页面: 476-480
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237526
- DOI: https://doi.org/10.1007/s10517-016-3442-y
- ID: 237526
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详细
Activation of the sympathetic nervous system aggravates the course of myocardial infarction. Semax peptide moderated the degree of this activation and prevented the increase in the density of sympathetic endings in rat caudal artery in 28 days after ischemia or ischemia/reperfusion. The peptide reduced the density of α-adrenoreceptors in the caudal artery of rats with myocardial infarction. Semax produced no effect on β-adrenoreceptors in both experimental models. The experiments on isolated segments of the caudal artery revealed reduced vascular responsiveness to electrical stimulation and norepinephrine infusion in rats treated with Semax after ischemia/reperfusion injury.
作者简介
A. Gorbacheva
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
A. Berdalin
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
A. Stulova
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
A. Nikogosova
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
M. Lin
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
S. Buravkov
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
S. Gavrilova
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow
V. Koshelev
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
俄罗斯联邦, Moscow