Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide
- Autores: Gorbacheva A.1, Berdalin A.1, Stulova A.1, Nikogosova A.1, Lin M.1, Buravkov S.1, Gavrilova S.1, Koshelev V.1
-
Afiliações:
- Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
- Edição: Volume 161, Nº 4 (2016)
- Páginas: 476-480
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237526
- DOI: https://doi.org/10.1007/s10517-016-3442-y
- ID: 237526
Citar
Resumo
Activation of the sympathetic nervous system aggravates the course of myocardial infarction. Semax peptide moderated the degree of this activation and prevented the increase in the density of sympathetic endings in rat caudal artery in 28 days after ischemia or ischemia/reperfusion. The peptide reduced the density of α-adrenoreceptors in the caudal artery of rats with myocardial infarction. Semax produced no effect on β-adrenoreceptors in both experimental models. The experiments on isolated segments of the caudal artery revealed reduced vascular responsiveness to electrical stimulation and norepinephrine infusion in rats treated with Semax after ischemia/reperfusion injury.
Sobre autores
A. Gorbacheva
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
A. Berdalin
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
A. Stulova
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
A. Nikogosova
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
M. Lin
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
S. Buravkov
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
S. Gavrilova
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow
V. Koshelev
Department of Physiology and General Pathology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: ann.gorbachewa@yandex.ru
Rússia, Moscow