Effect of Fluoxetine on Neurogenesis in Hippocampal Dentate Gyrus after Global Transient Cerebral Ischemia in Rats
- 作者: Khodanovich M.1, Kisel’ A.1, Chernysheva G.2, Smol’yakova V.2, Savchenko R.1, Plotnikov M.2
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隶属关系:
- Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University
- Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- 期: 卷 161, 编号 3 (2016)
- 页面: 351-354
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237410
- DOI: https://doi.org/10.1007/s10517-016-3412-4
- ID: 237410
如何引用文章
详细
Changes in cerebral neurogenesis provoked by ischemia and the effect of fluoxetine on this process were studied using a three-vessel occlusion model of global transient cerebral ischemia. The global transient cerebral ischemia was modeled on male Wistar rats by transient occlusion of three major vessels originating from the aortic arch and supplying the brain (brachiocephalic trunk, left subclavian artery, and left common carotid artery). The cells expressing doublecortin (DCX, a marker of young neurons) were counted in the hippocampal dentate gyrus on day 31 after ischemia modeling. It was found that ischemia inhibited neurogenesis in the dentate gyrus in comparison with sham-operated controls (p<0.05), while fluoxetine (20 mg/kg/day) injected over 10 days after surgery restored neurogenesis to the control level (p<0.001).
作者简介
M. Khodanovich
Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University
编辑信件的主要联系方式.
Email: khodanovich@mail.tsu.ru
俄罗斯联邦, Tomsk
A. Kisel’
Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University
Email: khodanovich@mail.tsu.ru
俄罗斯联邦, Tomsk
G. Chernysheva
Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: khodanovich@mail.tsu.ru
俄罗斯联邦, Tomsk
V. Smol’yakova
Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: khodanovich@mail.tsu.ru
俄罗斯联邦, Tomsk
R. Savchenko
Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University
Email: khodanovich@mail.tsu.ru
俄罗斯联邦, Tomsk
M. Plotnikov
Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: khodanovich@mail.tsu.ru
俄罗斯联邦, Tomsk