Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects
- 作者: Zhavbert E.1, Surkova E.1, Yakovleva N.1, Dugina Y.1, Epshtein O.1, Bugaeva L.2, Lebedeva S.2, Petrov V.2
-
隶属关系:
- Materia Medica Holding
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 161, 编号 2 (2016)
- 页面: 252-256
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237308
- DOI: https://doi.org/10.1007/s10517-016-3389-z
- ID: 237308
如何引用文章
详细
We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation containing a combination of affinity-purified antibodies to C-terminal fragment of angiotensin II type 1 receptor and endothelial NO-synthase), and Bation (release-active preparation containing a combination of affinity-purified antibodies to IFN-γ and CD4). We evaluated not only side and toxic effects, but also the relationships between these effects and pharmacological activities of the preparations. The data of preclinical toxicological studies of the release-active preparations can be used for prediction of their pharmacological activity.
作者简介
E. Zhavbert
Materia Medica Holding
编辑信件的主要联系方式.
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Moscow
E. Surkova
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Moscow
N. Yakovleva
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Moscow
Yu. Dugina
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Moscow
O. Epshtein
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Moscow
L. Bugaeva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Volgograd
S. Lebedeva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Volgograd
V. Petrov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhavbertes@materiamedica.ru
俄罗斯联邦, Volgograd