Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects
- Авторы: Zhavbert E.1, Surkova E.1, Yakovleva N.1, Dugina Y.1, Epshtein O.1, Bugaeva L.2, Lebedeva S.2, Petrov V.2
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Учреждения:
- Materia Medica Holding
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 161, № 2 (2016)
- Страницы: 252-256
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237308
- DOI: https://doi.org/10.1007/s10517-016-3389-z
- ID: 237308
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Аннотация
We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation containing a combination of affinity-purified antibodies to C-terminal fragment of angiotensin II type 1 receptor and endothelial NO-synthase), and Bation (release-active preparation containing a combination of affinity-purified antibodies to IFN-γ and CD4). We evaluated not only side and toxic effects, but also the relationships between these effects and pharmacological activities of the preparations. The data of preclinical toxicological studies of the release-active preparations can be used for prediction of their pharmacological activity.
Об авторах
E. Zhavbert
Materia Medica Holding
Автор, ответственный за переписку.
Email: zhavbertes@materiamedica.ru
Россия, Moscow
E. Surkova
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
Россия, Moscow
N. Yakovleva
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
Россия, Moscow
Yu. Dugina
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
Россия, Moscow
O. Epshtein
Materia Medica Holding
Email: zhavbertes@materiamedica.ru
Россия, Moscow
L. Bugaeva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhavbertes@materiamedica.ru
Россия, Volgograd
S. Lebedeva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhavbertes@materiamedica.ru
Россия, Volgograd
V. Petrov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhavbertes@materiamedica.ru
Россия, Volgograd
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