Anticoagulant Effects of Heparin Complexes with Prolyl-Glycine Peptide and Glycine and Proline Amino Acids
- 作者: Grigorieva M.1, Obergan T.1, Maystrenko E.1, Kalugina M.1
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隶属关系:
- M. V. Lomonosov Moscow State University
- 期: 卷 161, 编号 1 (2016)
- 页面: 54-57
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237086
- DOI: https://doi.org/10.1007/s10517-016-3343-0
- ID: 237086
如何引用文章
详细
The study demonstrates the formation of heparin complexes with prolyl-glycine peptide and proline and glycine amino acids. The method was developed for in vitro production of these complexes at 1:1 dipeptide to heparin molar ratio and 2:1 amino acid to heparin molar ratio. These complexes, unlike the constituents, proline and glycine, exhibited significant anticoagulant, antiplatelet, and fibrin-depolymerization activities of varying degree in vitro and in vivo. The heparin–dipeptide complex produced maximum effect. The dipeptide by itself also showed anticoagulant properties, but less pronounced than in the complex with heparin.
作者简介
M. Grigorieva
M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: mgrigorjeva@mail.ru
俄罗斯联邦, Moscow
T. Obergan
M. V. Lomonosov Moscow State University
Email: mgrigorjeva@mail.ru
俄罗斯联邦, Moscow
E. Maystrenko
M. V. Lomonosov Moscow State University
Email: mgrigorjeva@mail.ru
俄罗斯联邦, Moscow
M. Kalugina
M. V. Lomonosov Moscow State University
Email: mgrigorjeva@mail.ru
俄罗斯联邦, Moscow