Anticoagulant Effects of Heparin Complexes with Prolyl-Glycine Peptide and Glycine and Proline Amino Acids
- Authors: Grigorieva M.E.1, Obergan T.Y.1, Maystrenko E.S.1, Kalugina M.D.1
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Affiliations:
- M. V. Lomonosov Moscow State University
- Issue: Vol 161, No 1 (2016)
- Pages: 54-57
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237086
- DOI: https://doi.org/10.1007/s10517-016-3343-0
- ID: 237086
Cite item
Abstract
The study demonstrates the formation of heparin complexes with prolyl-glycine peptide and proline and glycine amino acids. The method was developed for in vitro production of these complexes at 1:1 dipeptide to heparin molar ratio and 2:1 amino acid to heparin molar ratio. These complexes, unlike the constituents, proline and glycine, exhibited significant anticoagulant, antiplatelet, and fibrin-depolymerization activities of varying degree in vitro and in vivo. The heparin–dipeptide complex produced maximum effect. The dipeptide by itself also showed anticoagulant properties, but less pronounced than in the complex with heparin.
About the authors
M. E. Grigorieva
M. V. Lomonosov Moscow State University
Author for correspondence.
Email: mgrigorjeva@mail.ru
Russian Federation, Moscow
T. Yu. Obergan
M. V. Lomonosov Moscow State University
Email: mgrigorjeva@mail.ru
Russian Federation, Moscow
E. S. Maystrenko
M. V. Lomonosov Moscow State University
Email: mgrigorjeva@mail.ru
Russian Federation, Moscow
M. D. Kalugina
M. V. Lomonosov Moscow State University
Email: mgrigorjeva@mail.ru
Russian Federation, Moscow