Effects of Deep Cooling and Re-Warming on Ionotropic Glutamatergic Receptors In Vitro
- 作者: Mokrushin A.1
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隶属关系:
- Laboratory of Regulation for Functions of Brain Neurons, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- 期: 卷 161, 编号 1 (2016)
- 页面: 28-31
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237061
- DOI: https://doi.org/10.1007/s10517-016-3337-y
- ID: 237061
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详细
We studied the effects of cooling to -10°C and re-warming to 37°C on slices of rat olfactory cortex. The amplitudes of action potential in the lateral olfactory tract and excitatory postsynaptic potential activated by AMPA recovered during slow cooling/re-warming (0.1°C/min), while during rapid cooling/re-warming (9°C/min), they surpassed the control values. NMDA receptor-dependent mechanism was blocked in both cooling/re-warming modes. Swelling of the brain slices was observed during re-warming, especially during rapid cooling/re-warming. Nerve fibers of the lateral olfactory tract and AMPA-related processes survived deep cooling/re-warming, while NMDA-related processes were irreversibly blocked.
作者简介
A. Mokrushin
Laboratory of Regulation for Functions of Brain Neurons, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: mok@inbox.ru
俄罗斯联邦, St. Petersburg