Anxiolytic, Psychostimulant, and Analgesic Effects of Various Volumes of Ethanol Solution in Different Concentrations, but in the Same Dose
- 作者: Sudakov S.1, Alekseeva E.1, Bogdanova N.1, Kolpakov A.1, Nazarova G.1
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隶属关系:
- P. K. Anokhin Research Institute of Normal Physiology
- 期: 卷 161, 编号 1 (2016)
- 页面: 1-3
- 栏目: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237044
- DOI: https://doi.org/10.1007/s10517-016-3330-5
- ID: 237044
如何引用文章
详细
We studied the effect of ethanol (dose 2 g/kg) in various concentrations (5, 13, and 40%) and different volumes (40, 15.5, and 5 ml/kg) on the level of anxiety, locomotor activity, and pain sensitivity in rats. Administration of 40 ml/kg water to animals was followed by a significant increase in the time spent in the open arms of the elevated plus maze. Administration of water in a volume of 5 or 15.5 ml/kg had little effect on the level of anxiety. The greater was the volume of intragastrically administered ethanol, the stronger was the anxiolytic effect. The psychostimulant and analgesic effects of ethanol were more pronounced after administration of medium volumes and intermediate concentrations of ethanol-containing solutions. Since administration of these solutions cannot produce maximum blood concentration of ethanol, we believe that the observed effects are mainly related to the direct effect of ethanol on the stomach tissue.
作者简介
S. Sudakov
P. K. Anokhin Research Institute of Normal Physiology
编辑信件的主要联系方式.
Email: s-sudakov@nphys.ru
俄罗斯联邦, Moscow
E. Alekseeva
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
俄罗斯联邦, Moscow
N. Bogdanova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
俄罗斯联邦, Moscow
A. Kolpakov
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
俄罗斯联邦, Moscow
G. Nazarova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
俄罗斯联邦, Moscow