Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid
- 作者: Tyurenkov I.1, Borodkina L.1, Bagmetova V.1, Berestovitskaya V.2, Vasil’eva O.2
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隶属关系:
- Volgograd State Medical University
- A. I. Herzen State Pedagogical University of Russia
- 期: 卷 160, 编号 4 (2016)
- 页面: 465-469
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236735
- DOI: https://doi.org/10.1007/s10517-016-3198-4
- ID: 236735
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详细
GABA analogs containing phenyl (phenibut) or para-chlorophenyl (baclofen) substituents demonstrated nootropic activity in a dose of 20 mg/kg: they improved passive avoidance conditioning, decelerated its natural extinction, and exerted antiamnestic effect on the models of amnesia provoked by scopolamine or electroshock. Tolyl-containing GABA analog (tolibut, 20 mg/kg) exhibited antiamnestic activity only on the model of electroshock-induced amnesia. Baclofen and, to a lesser extent, tolibut alleviated seizures provoked by electroshock, i.e. both agents exerted anticonvulsant effect. All examined GABA aryl derivatives demonstrated neuroprotective properties on the maximum electroshock model: they shortened the duration of coma and shortened the period of spontaneous motor activity recovery. In addition, these agents decreased the severity of passive avoidance amnesia and behavioral deficit in the open field test in rats exposed to electroshock. The greatest neuroprotective properties were exhibited by phenyl-containing GABA analog phenibut.
作者简介
I. Tyurenkov
Volgograd State Medical University
Email: vvbagmetova@gmail.ru
俄罗斯联邦, Volgograd
L. Borodkina
Volgograd State Medical University
Email: vvbagmetova@gmail.ru
俄罗斯联邦, Volgograd
V. Bagmetova
Volgograd State Medical University
编辑信件的主要联系方式.
Email: vvbagmetova@gmail.ru
俄罗斯联邦, Volgograd
V. Berestovitskaya
A. I. Herzen State Pedagogical University of Russia
Email: vvbagmetova@gmail.ru
俄罗斯联邦, St. Petersburg
O. Vasil’eva
A. I. Herzen State Pedagogical University of Russia
Email: vvbagmetova@gmail.ru
俄罗斯联邦, St. Petersburg