Role of Nitric Oxide Produced by Lactobacilli in Relaxation of Intestinal Smooth Muscles


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Application of NO-producing lactobacilli to a rat jejunum segment induced muscle relaxation that was potentiated after activation of bacterial NO production with NO synthase substrate L-arginine. Similar changes in the intestinal contractile activity were observed in response to exogenous NO formed by sodium nitroprusside. These results indicated the involvement of NO synthesized by probiotic lactobacilli in the regulation of the intestinal motor function.

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D. Yarullina

Department of Microbiology, Kazan (Volga Region) Federal University

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俄罗斯联邦, Kazan

R. Mikheeva

Department of Human and Animal Physiology, Kazan (Volga Region) Federal University

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俄罗斯联邦, Kazan

G. Sabirullina

Department of Human and Animal Physiology, Kazan (Volga Region) Federal University

Email: kasfes@gmail.com
俄罗斯联邦, Kazan

P. Zelenikhin

Department of Microbiology, Kazan (Volga Region) Federal University

Email: kasfes@gmail.com
俄罗斯联邦, Kazan

O. Ilinskaya

Department of Microbiology, Kazan (Volga Region) Federal University

Email: kasfes@gmail.com
俄罗斯联邦, Kazan

G. Sitdikova

Department of Human and Animal Physiology, Kazan (Volga Region) Federal University

Email: kasfes@gmail.com
俄罗斯联邦, Kazan


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