Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy
- Авторы: Abramicheva P.1, Kostenko Y.1, Balakina T.1, Smirnova O.1
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Учреждения:
- M. V. Lomonosov Moscow State University
- Выпуск: Том 168, № 2 (2019)
- Страницы: 219-223
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242371
- DOI: https://doi.org/10.1007/s10517-019-04678-8
- ID: 242371
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Аннотация
We analyzed the expression of molecular targets of natriuretic action of prolactin in different layers of the kidney in the rat model of cholestasis of pregnancy. Sodium bicarbonate cotransporter NBCe1 was most sensitive to the conditions of cholestasis and cholestasis of pregnancy: the expression NBCe1 mRNA and protein in the renal outer medulla decreased in comparison with the normal. All forms of cholestasis affected the mRNA expression of sodium-potassium chloride co-transporter NCC, α-subunit of the ENaCα epithelial sodium channel, and Nedd4-2 ubiquitin ligase in different layers of the kidney. The obtained data suggest that prolactin provides fine tuning of various sodium transporters in different parts of the nephron under pathological conditions.
Об авторах
P. Abramicheva
M. V. Lomonosov Moscow State University
Автор, ответственный за переписку.
Email: abramicheva.polina@gmail.com
Россия, Moscow
Yu. Kostenko
M. V. Lomonosov Moscow State University
Email: abramicheva.polina@gmail.com
Россия, Moscow
T. Balakina
M. V. Lomonosov Moscow State University
Email: abramicheva.polina@gmail.com
Россия, Moscow
O. Smirnova
M. V. Lomonosov Moscow State University
Email: abramicheva.polina@gmail.com
Россия, Moscow
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