Induction of Osteogenesis in Rat Bone Tissue Using Cryogenically Structured Porous 3D Materials Containing a Bioregulator
- Авторы: Krasnov M.1, Shaikhaliev A.2, Korshakov E.2, Efimenko M.2, Soloshenkov P.2, Davidova T.2, Zvukova N.1, Sinitskaya E.1, Yamskova V.2, Yamskov I.1, Lozinsky V.1
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Учреждения:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
- Выпуск: Том 168, № 1 (2019)
- Страницы: 99-103
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242254
- DOI: https://doi.org/10.1007/s10517-019-04657-z
- ID: 242254
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Аннотация
We studied osteogenesis induction after implantation of porous cryogenically structured 3D scaffolds based on chitosan, alginate, and serum albumin and containing a bioregulator from bovine serum into in vivo modeled experimental bone defect in rats. It was shown that such 3D-matrices are effective as osteoconductors due to their effect on osteoblast precursors. All types of bioregulator-loaded 3D materials promote active bone repair, which manifested in restoration of the dense bone tissue, formation of the bone marrow, and the recovery of osteons on day 14 after surgery. In animals receiving implantation of control 3D scaffolds without the bioregulator, the formation of dense fibrous tissue and spongy bone was observed by this term.
Об авторах
M. Krasnov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: embrmsk@mail.ru
Россия, Moscow
A. Shaikhaliev
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: embrmsk@mail.ru
Россия, Moscow
E. Korshakov
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: embrmsk@mail.ru
Россия, Moscow
M. Efimenko
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: embrmsk@mail.ru
Россия, Moscow
P. Soloshenkov
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: embrmsk@mail.ru
Россия, Moscow
T. Davidova
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: embrmsk@mail.ru
Россия, Moscow
N. Zvukova
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: embrmsk@mail.ru
Россия, Moscow
E. Sinitskaya
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: embrmsk@mail.ru
Россия, Moscow
V. Yamskova
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: embrmsk@mail.ru
Россия, Moscow
I. Yamskov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: embrmsk@mail.ru
Россия, Moscow
V. Lozinsky
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: embrmsk@mail.ru
Россия, Moscow