Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction
- Авторы: Tsorin I.1, Barchukov V.1, Vititnova M.1, Kryzhanovskii S.1, Seredenin S.1
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Учреждения:
- V. V. Zakusov Research Institute of Pharmacology
- Выпуск: Том 167, № 5 (2019)
- Страницы: 634-636
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241976
- DOI: https://doi.org/10.1007/s10517-019-04586-x
- ID: 241976
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Аннотация
Anti-ischemic activity of fabomotizole hydrochloride was studied on the model of subendocardial ischemia in rats with endothelial dysfunction. Endothelial dysfunction was modeled by intragastric administration of methionine (3 g/kg, once a day for 7 days). Acute subendocardial ischemia was induced in narcotized rats by intraperitoneal injection of isoproterenol (20 μg/kg/min over 5 min). Fabomotizole hydrochloride (intraperitoneally, 15 mg/kg) significantly reduced isoproterenol-induced ST segment depression in animals with endothelial dysfunction and with intact vasculature.
Об авторах
I. Tsorin
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Россия, Moscow
V. Barchukov
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Россия, Moscow
M. Vititnova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Россия, Moscow
S. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology
Автор, ответственный за переписку.
Email: SAK-538@yandex.ru
Россия, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Россия, Moscow