Endogenous Opioid Dependence Induced in Rats by Periodic Intake of 5% Ethanol Solution
- Авторы: Sudakov S.1, Bogdanova N.1, Alekseeva E.1, Nazarova G.1
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Учреждения:
- P. K. Anokhin Research Institute of Normal Physiology
- Выпуск: Том 167, № 3 (2019)
- Страницы: 301-304
- Раздел: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241668
- DOI: https://doi.org/10.1007/s10517-019-04514-z
- ID: 241668
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Аннотация
We studied the possibility of formation of endogenous opioid dependence in rats during periodic intake of 5% ethanol solution. In the control group, both drinking bottles contained water. In the experimental group, the second bottle was filled with 5% ethanol solution for 12 h per day; in the following 12 h, these rats were deprived of food and ethanol. This regimen was maintained over 8 days. The rats were subdivided into alcohol- and water-preferring subgroups. Ethanol deprivation followed by naloxone injection evoked the signs of opiate withdrawal syndrome in both subgroups. These findings suggest that periodic voluntary intake of a weak ethanol solution over 8 days led to the formation of endogenous opioid dependence in rats irrespective of amount of the consumed alcohol.
Об авторах
S. Sudakov
P. K. Anokhin Research Institute of Normal Physiology
Автор, ответственный за переписку.
Email: s-sudakov@nphys.ru
Россия, Moscow
N. Bogdanova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Россия, Moscow
E. Alekseeva
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Россия, Moscow
G. Nazarova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Россия, Moscow