Endogenous Opioid Dependence Induced in Rats by Periodic Intake of 5% Ethanol Solution
- Autores: Sudakov S.1, Bogdanova N.1, Alekseeva E.1, Nazarova G.1
-
Afiliações:
- P. K. Anokhin Research Institute of Normal Physiology
- Edição: Volume 167, Nº 3 (2019)
- Páginas: 301-304
- Seção: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241668
- DOI: https://doi.org/10.1007/s10517-019-04514-z
- ID: 241668
Citar
Resumo
We studied the possibility of formation of endogenous opioid dependence in rats during periodic intake of 5% ethanol solution. In the control group, both drinking bottles contained water. In the experimental group, the second bottle was filled with 5% ethanol solution for 12 h per day; in the following 12 h, these rats were deprived of food and ethanol. This regimen was maintained over 8 days. The rats were subdivided into alcohol- and water-preferring subgroups. Ethanol deprivation followed by naloxone injection evoked the signs of opiate withdrawal syndrome in both subgroups. These findings suggest that periodic voluntary intake of a weak ethanol solution over 8 days led to the formation of endogenous opioid dependence in rats irrespective of amount of the consumed alcohol.
Sobre autores
S. Sudakov
P. K. Anokhin Research Institute of Normal Physiology
Autor responsável pela correspondência
Email: s-sudakov@nphys.ru
Rússia, Moscow
N. Bogdanova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Rússia, Moscow
E. Alekseeva
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Rússia, Moscow
G. Nazarova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Rússia, Moscow
![](/img/style/loading.gif)