Mesenchymal Stem Cells from Mouse Adipose Tissue Stimulate Tumor Growth


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Аннотация

We studied the effect of mesenchymal stem cells from the bone marrow and adipose tissue on the growth rate of melanoma B16 and mammary adenocarcinoma Ca755 tumors after their co-administration with tumor cells to syngeneic mice. Stimulation of tumor growth and formation of melanoma metastases in the lungs was found under the influence of adipose tissue-derived, but not bone marrow-derived stem cells. At delayed terms after irradiation in sublethal doses, the adipose tissue-derived mesenchymal stem cells also stimulated the tumor growth. Stimulation of the tumor growth by adipose tissue-derived mesenchymal stem cells was caused by factors secreted by these cells. Transplantation of mesenchymal stem cells to humans is possible only after accurate exclusion of malignant tumors.

Об авторах

E. Moskaleva

Laboratory of Cell Biology and Molecular Medicine, National Research Center Kurchatov Institute

Автор, ответственный за переписку.
Email: moskalevaey@mail.ru
Россия, Moscow

Yu. Semochkina

Laboratory of Cell Biology and Molecular Medicine, National Research Center Kurchatov Institute

Email: moskalevaey@mail.ru
Россия, Moscow

V. Shuvatova

Laboratory of Cell Biology and Molecular Medicine, National Research Center Kurchatov Institute

Email: moskalevaey@mail.ru
Россия, Moscow

A. Rodina

Laboratory of Cell Biology and Molecular Medicine, National Research Center Kurchatov Institute

Email: moskalevaey@mail.ru
Россия, Moscow

A. Krasheninnikova

Laboratory of Cell Biology and Molecular Medicine, National Research Center Kurchatov Institute

Email: moskalevaey@mail.ru
Россия, Moscow


© Springer Science+Business Media, LLC, part of Springer Nature, 2019

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