Regenerative Potential of Spinal Ganglion Neurons During Topical Administration of Platelet-Enriched Blood Plasma Into the Skin Wound
- Авторы: Fetisov S.1, Nikityuk D.2, Klochkova S.3, Alekseeva N.1, Kvaratskheliya A.1
-
Учреждения:
- Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
- Federal Research Center of Nutrition, Biotechnology, and Food Safety, Russian Academy of Sciences
- Department of Human Anatomy, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 165, № 6 (2018)
- Страницы: 808-812
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240762
- DOI: https://doi.org/10.1007/s10517-018-4270-z
- ID: 240762
Цитировать
Аннотация
We studied the reactions of spinal ganglion neurons accompanying regeneration of the skin wound complicated by S. aureus sp. infection. The appearance of neuron groups with different morphofunctional changes was noted: reversible dystrophic and compensatory reactions and irreversible degenerative changes. The proportion of small B neurons was higher than the proportion of large type A neurons at all terms of the experiment. Application of plateletrich plasma to the wound after preliminary hydroimpulsive treatment considerably reduced cell destruction and stimulated regenerative effects in neurons starting from day 7 of the experiment. Application of platelet-rich plasma without hydroimpulsive treatment decelerated wound regeneration and increased the number of destructively changed neurons even in comparison with spontaneous wound healing. Close correlations between protein synthesis markers and stages of the wound process and its characteristics were revealed.
Об авторах
S. Fetisov
Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
Автор, ответственный за переписку.
Email: fetisovbiol@yandex.ru
Россия, Voronezh
D. Nikityuk
Federal Research Center of Nutrition, Biotechnology, and Food Safety, Russian Academy of Sciences
Email: fetisovbiol@yandex.ru
Россия, Moscow
S. Klochkova
Department of Human Anatomy, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: fetisovbiol@yandex.ru
Россия, Moscow
N. Alekseeva
Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
Email: fetisovbiol@yandex.ru
Россия, Voronezh
A. Kvaratskheliya
Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
Email: fetisovbiol@yandex.ru
Россия, Voronezh
![](/img/style/loading.gif)