Regenerative Potential of Spinal Ganglion Neurons During Topical Administration of Platelet-Enriched Blood Plasma Into the Skin Wound
- Авторлар: Fetisov S.1, Nikityuk D.2, Klochkova S.3, Alekseeva N.1, Kvaratskheliya A.1
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Мекемелер:
- Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
- Federal Research Center of Nutrition, Biotechnology, and Food Safety, Russian Academy of Sciences
- Department of Human Anatomy, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 6 (2018)
- Беттер: 808-812
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240762
- DOI: https://doi.org/10.1007/s10517-018-4270-z
- ID: 240762
Дәйексөз келтіру
Аннотация
We studied the reactions of spinal ganglion neurons accompanying regeneration of the skin wound complicated by S. aureus sp. infection. The appearance of neuron groups with different morphofunctional changes was noted: reversible dystrophic and compensatory reactions and irreversible degenerative changes. The proportion of small B neurons was higher than the proportion of large type A neurons at all terms of the experiment. Application of plateletrich plasma to the wound after preliminary hydroimpulsive treatment considerably reduced cell destruction and stimulated regenerative effects in neurons starting from day 7 of the experiment. Application of platelet-rich plasma without hydroimpulsive treatment decelerated wound regeneration and increased the number of destructively changed neurons even in comparison with spontaneous wound healing. Close correlations between protein synthesis markers and stages of the wound process and its characteristics were revealed.
Авторлар туралы
S. Fetisov
Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
Хат алмасуға жауапты Автор.
Email: fetisovbiol@yandex.ru
Ресей, Voronezh
D. Nikityuk
Federal Research Center of Nutrition, Biotechnology, and Food Safety, Russian Academy of Sciences
Email: fetisovbiol@yandex.ru
Ресей, Moscow
S. Klochkova
Department of Human Anatomy, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: fetisovbiol@yandex.ru
Ресей, Moscow
N. Alekseeva
Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
Email: fetisovbiol@yandex.ru
Ресей, Voronezh
A. Kvaratskheliya
Department of Normal Human Anatomy, N. N. Burdenko Voronezh State Medical University
Email: fetisovbiol@yandex.ru
Ресей, Voronezh