Effects Mifepristone on Aminotransferase Activities in the Liver in Rats with Streptozotocin-Induced Diabetes Mellitus
- Авторы: Pal’chikova N.1, Selyatitskaya V.1, Kuz’minova O.1, Pasechnaya K.1
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Учреждения:
- Research Institute of Experimental and Clinical Medicine
- Выпуск: Том 165, № 4 (2018)
- Страницы: 474-477
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240432
- DOI: https://doi.org/10.1007/s10517-018-4197-4
- ID: 240432
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Аннотация
The glucocorticoid status and activities of ALT, AST, and tyrosine aminotransferase in the liver are studied in rats with streptozotocin-induced diabetes mellitus in response to repeated intraperitoneal injections of mifepristone. Diabetic rats develop an increase of the blood corticosterone and liver aminotransferase levels in response to mifepristone. These results indicate that in diabetic animals the glucocorticoid hormones with high blood concentrations, increasing still more in response to mifepristone, overcome the receptor blockade, and realize their regulatory functions in hepatocytes. The effects of mifepristone on ALT activity are the most manifest. In normal rats, only ALT activity is increasing in response to mifepristone, while in rats with streptozotocin-induced diabetes mellitus, ALT activity increases more intensely than activities of tyrosine aminotransferase and AST.
Об авторах
N. Pal’chikova
Research Institute of Experimental and Clinical Medicine
Автор, ответственный за переписку.
Email: labend@mail.ru
Россия, Novosibirsk
V. Selyatitskaya
Research Institute of Experimental and Clinical Medicine
Email: labend@mail.ru
Россия, Novosibirsk
O. Kuz’minova
Research Institute of Experimental and Clinical Medicine
Email: labend@mail.ru
Россия, Novosibirsk
K. Pasechnaya
Research Institute of Experimental and Clinical Medicine
Email: labend@mail.ru
Россия, Novosibirsk
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