Study of the Oxime-induced Reactivation of Acetyl- and Butyrylcholinesterase of Human with Inhibition of Organophosphorus Insecticide In Vitro
- Авторы: Kolesnikov A.1, Yuidin M.1, Nikiforov A.1, Ivanov I.1, Vengerovich N.1, Makacheev A.1
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Учреждения:
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Выпуск: Том 164, № 5 (2018)
- Страницы: 624-628
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239794
- DOI: https://doi.org/10.1007/s10517-018-4046-5
- ID: 239794
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Аннотация
The efficiency of different reactivators of cholinesterase (toxogonin, dipiroxime, pralidoxime, carboxim, HI-6, and methoxime) at inhibition of butyrylcholinesterase and human acetylcholinesterase by organophosphate insecticide malathion was evaluated in in vitro experiments. Most reactivators increased inhibition of butyrylcholinesterase in comparison with the control, but HI-6 in a concentration of 10—3 mol/liter partially (10%) restored activity of the enzyme. Oxime-induced reactivation of acetylcholinesterase was most pronounced in dipyroxime and toxogonin: parameters of the kinetics of reduction of the phosphorylated enzyme differed by more than 2 times from the values received with the use of other reactivators.
Об авторах
A. Kolesnikov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Автор, ответственный за переписку.
Email: alex9_6_89@mail.ru
Россия, St. Petersburg
M. Yuidin
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: alex9_6_89@mail.ru
Россия, St. Petersburg
A. Nikiforov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: alex9_6_89@mail.ru
Россия, St. Petersburg
I. Ivanov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: alex9_6_89@mail.ru
Россия, St. Petersburg
N. Vengerovich
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: alex9_6_89@mail.ru
Россия, St. Petersburg
A. Makacheev
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: alex9_6_89@mail.ru
Россия, St. Petersburg