Role of Matrix Metalloproteinase-2 in the Development of Cyclophosphamide-Induced Cardiomyopathy
- Авторы: Koldysheva E.1, Klinnikova M.1, Nikityuk D.1, Ivleva E.1, Listvyagova N.1, Lushnikova E.1
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Учреждения:
- Institute of Molecular Pathology and Pathomorphology
- Выпуск: Том 164, № 4 (2018)
- Страницы: 483-487
- Раздел: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/239701
- DOI: https://doi.org/10.1007/s10517-018-4017-x
- ID: 239701
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Аннотация
Immunohistochemical assay was employed to determine localization of MMP-2 in cardiomyocytes of WAG rats and changes in MMP-2 expression during modeled cardiomyopathy induced by single intraperitoneal injection of cyclophosphamide (125 mg/kg) alone or in combination with preventive intraperitoneal administration of an equal dose of asparcam-L (potassium-magnesium asparaginate) 30 min prior to the cytostatic. In the myocardium of control and experimental rats, MMP-2 was mostly located in cardiomyocyte nuclei. During the development of cyclophosphamide-induced cardiomyopathy (in 3 days after injection), the index of MMP-2-positive cardiomyocyte nuclei increased by 76%. In contrast to control hearts, MMP-2 was also expressed in the cardiomyocyte sarcoplasm. Preventive injection of asparcam-L moderated the cardiotoxic effect of cyclophosphamide, which manifested in less pronounced increase in the volume density of cardiomyocytes with lytic changes (by 42%) and index of MMP-2+ cardiomyocyte nuclei (by 23%) in comparison with the rats exposed to cyclophosphamide alone.
Об авторах
E. Koldysheva
Institute of Molecular Pathology and Pathomorphology
Автор, ответственный за переписку.
Email: pathol@inbox.ru
Россия, Novosibirsk
M. Klinnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
D. Nikityuk
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
E. Ivleva
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
N. Listvyagova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
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