Inactivation of M111 Protein Gene Modifies Streptococcus Pyogenes Interactions with Mouse Macrophages In Vitro
- Авторы: Suvorova M.1, Kramskaya T.1, Suvorov A.1, Kiseleva E.1,2
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Учреждения:
- Institute of Experimental Medicine
- I. I. Mechnikov North-Western State Medical University
- Выпуск: Том 164, № 3 (2018)
- Страницы: 347-350
- Раздел: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/239593
- DOI: https://doi.org/10.1007/s10517-018-3987-z
- ID: 239593
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Аннотация
Immunomodulatory properties of S. pyogenes protein M111 were studied on the model of Gurov strain and its isogenic mutant not expressing M protein. Mouse resident peritoneal macrophages were incubated with bacteria and generation of nitroxide and superoxide anions and production of IL-6, IL-10, and IL-17 were evaluated. Protein M111 modified macrophage response: it exhibited antiphagocytic activity, prevented ROS formation, and stimulated the production of anti-inflammatory cytokine IL-10. The results suggested that this protein could serve in the bacteria as a factor suppressing the host defense forces and promoting the realization of the strategy beneficial for pathogens — escape from the host immune defense.
Об авторах
M. Suvorova
Institute of Experimental Medicine
Автор, ответственный за переписку.
Email: maria_suvorova@mail.ru
Россия, St. Petersburg
T. Kramskaya
Institute of Experimental Medicine
Email: maria_suvorova@mail.ru
Россия, St. Petersburg
A. Suvorov
Institute of Experimental Medicine
Email: maria_suvorova@mail.ru
Россия, St. Petersburg
E. Kiseleva
Institute of Experimental Medicine; I. I. Mechnikov North-Western State Medical University
Email: maria_suvorova@mail.ru
Россия, St. Petersburg; St. Petersburg