Rhythmoinotropic Response of Papillary Muscles in Rats with Different Severity of Postinfarction Cardiosclerosis
- Авторы: Kondratieva D.1, Afanasiev S.1, Usov V.1, Popov S.1
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Учреждения:
- Research Institute of Cardiology
- Выпуск: Том 163, № 5 (2017)
- Страницы: 612-616
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239124
- DOI: https://doi.org/10.1007/s10517-017-3861-4
- ID: 239124
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Аннотация
We studied the dependence of post-rest positive inotropic response of isolated rat papillary muscles subjected to rhythmic stimulation on severity of postinfarction cardiosclerosis developed during 6 weeks after occlusion of the left descending coronary artery. The isolated papillary muscles were perfused with oxygenated Krebs—Henseleit solution and electrically stimulated at a rate of 0.5 Hz. In all rats, coronary occlusion provoked postinfarction cardiosclerosis with the formation of a scar occupying 20-50% (min-max of the sample) of the left ventricular wall. Despite the presence of large postinfarction scar in all rats, the positive post-rest inotropic responses greatly varied. The post-rest response in rats with scar occupying <37% left ventricular wall was similar to that in intact animals, but rats with scar area >44% demonstrated dramatically decreased inotropic response to rest periods.
Об авторах
D. Kondratieva
Research Institute of Cardiology
Автор, ответственный за переписку.
Email: dina@cardio-tomsk.ru
Россия, Tomsk
S. Afanasiev
Research Institute of Cardiology
Email: dina@cardio-tomsk.ru
Россия, Tomsk
V. Usov
Research Institute of Cardiology
Email: dina@cardio-tomsk.ru
Россия, Tomsk
S. Popov
Research Institute of Cardiology
Email: dina@cardio-tomsk.ru
Россия, Tomsk