Rhythmoinotropic Response of Papillary Muscles in Rats with Different Severity of Postinfarction Cardiosclerosis
- Authors: Kondratieva D.S.1, Afanasiev S.A.1, Usov V.Y.1, Popov S.V.1
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Affiliations:
- Research Institute of Cardiology
- Issue: Vol 163, No 5 (2017)
- Pages: 612-616
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239124
- DOI: https://doi.org/10.1007/s10517-017-3861-4
- ID: 239124
Cite item
Abstract
We studied the dependence of post-rest positive inotropic response of isolated rat papillary muscles subjected to rhythmic stimulation on severity of postinfarction cardiosclerosis developed during 6 weeks after occlusion of the left descending coronary artery. The isolated papillary muscles were perfused with oxygenated Krebs—Henseleit solution and electrically stimulated at a rate of 0.5 Hz. In all rats, coronary occlusion provoked postinfarction cardiosclerosis with the formation of a scar occupying 20-50% (min-max of the sample) of the left ventricular wall. Despite the presence of large postinfarction scar in all rats, the positive post-rest inotropic responses greatly varied. The post-rest response in rats with scar occupying <37% left ventricular wall was similar to that in intact animals, but rats with scar area >44% demonstrated dramatically decreased inotropic response to rest periods.
About the authors
D. S. Kondratieva
Research Institute of Cardiology
Author for correspondence.
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
S. A. Afanasiev
Research Institute of Cardiology
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
V. Yu. Usov
Research Institute of Cardiology
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk
S. V. Popov
Research Institute of Cardiology
Email: dina@cardio-tomsk.ru
Russian Federation, Tomsk