Peculiarities in Interaction of Independent Components of Resting-State fMRI Signal in Patients with Mild Depressions
- Авторы: Mel’nikov M.1,2, Bezmaternykh D.1,2, Petrovskii E.3, Kozlova L.1,2, Shtark M.1,2, Savelov A.3, Shubina O.1, Natarova K.4
-
Учреждения:
- Research Institute of Molecular Biology and Biophysics
- Novosibirsk National State Research University
- International Tomography Center, Siberian Division of the Russian Academy of Medical Sciences
- International Institute of Psychology and Psychotherapy
- Выпуск: Том 163, № 4 (2017)
- Страницы: 497-499
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239035
- DOI: https://doi.org/10.1007/s10517-017-3837-4
- ID: 239035
Цитировать
Аннотация
Some aspects of resting-state fMRI signal can be the key markers of depression. fMRI was recoded over 4 min in evidently healthy persons (N=21) and in patients with mild depression (N=21). The data were separated into the independent spatial components, and the strength of their association with established brain networks was analyzed. The patients with mild depression were characterized with greater correlations between the components representing the ventral and dorsal subdivisions of default mode network (DMN), whereas correlations between the components relating to cerebellum and to the left hemisphere language system were less pronounced. The data revealed a significant role of DMN in the development of affective abnormalities and importance of its functional state as a probable marker of mild depression.
Об авторах
M. Mel’nikov
Research Institute of Molecular Biology and Biophysics; Novosibirsk National State Research University
Автор, ответственный за переписку.
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk; Novosibirsk
D. Bezmaternykh
Research Institute of Molecular Biology and Biophysics; Novosibirsk National State Research University
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk; Novosibirsk
E. Petrovskii
International Tomography Center, Siberian Division of the Russian Academy of Medical Sciences
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk
L. Kozlova
Research Institute of Molecular Biology and Biophysics; Novosibirsk National State Research University
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk; Novosibirsk
M. Shtark
Research Institute of Molecular Biology and Biophysics; Novosibirsk National State Research University
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk; Novosibirsk
A. Savelov
International Tomography Center, Siberian Division of the Russian Academy of Medical Sciences
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk
O. Shubina
Research Institute of Molecular Biology and Biophysics
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk
K. Natarova
International Institute of Psychology and Psychotherapy
Email: mikhail-melnikov@mail.ru
Россия, Novosibirsk
![](/img/style/loading.gif)