Free Immunoglobulin Light Chains as Criteria of Extracorporeal Hemocorrection in Patients with Monoclonal Gammopathies
- Авторы: Lyubimova N.1, Timofeeva Y.1, Gromova E.1, Kuznetsova L.1, Votyakova O.1, Kushlinskii N.1
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Учреждения:
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- Выпуск: Том 163, № 4 (2017)
- Страницы: 493-496
- Раздел: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/239033
- DOI: https://doi.org/10.1007/s10517-017-3836-5
- ID: 239033
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Аннотация
Elimination of free immunoglobulin light chains with the use of EMic2 selective filters was carried out in 12 patients with monoclonal gammopathies and high production of free immunoglobulin light chains. We showed that extracorporeal detoxification for direct removal of excessive free immunoglobulin light chains from the circulation is advisable for these patients, irrespective of the presence and severity of renal insufficiency. Rapid reduction or elimination of free light chains of immunoglobulins in the course of selective extracorporeal elimination helps to prevent the development of irreversible renal failure and to perform adequate antitumor therapy.
Об авторах
N. Lyubimova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Россия, Moscow
Yu. Timofeeva
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Россия, Moscow
E. Gromova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Россия, Moscow
L. Kuznetsova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Россия, Moscow
O. Votyakova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Россия, Moscow
N. Kushlinskii
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: biochimia@yandex.ru
Россия, Moscow