Target Cell Glycosylation Determines the Biodistribution of Plant Lectin Viscumin
- Авторы: Maltseva D.1, Gerasimov V.1, Sakharov D.1, Shkurnikov M.1
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Учреждения:
- BioClinicum Research Center
- Выпуск: Том 163, № 4 (2017)
- Страницы: 482-485
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239013
- DOI: https://doi.org/10.1007/s10517-017-3833-8
- ID: 239013
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Аннотация
We studied the possibility of using viscumin lectin (MLI) for targeted delivery of antitumor drugs. Affinity of MLI for more than 600 oligosaccharide structures was determined and the glycosylation profiles of cell surface in various mouse tissues were analyzed. It was found that biodistribution of MLI was determined by not only expression of oligosaccharides specifically recognized by the lectin in tissue cells, but also by the structure of glycan in general.
Об авторах
D. Maltseva
BioClinicum Research Center
Автор, ответственный за переписку.
Email: d.maltseva@bioclinicum.com
Россия, Moscow
V. Gerasimov
BioClinicum Research Center
Email: d.maltseva@bioclinicum.com
Россия, Moscow
D. Sakharov
BioClinicum Research Center
Email: d.maltseva@bioclinicum.com
Россия, Moscow
M. Shkurnikov
BioClinicum Research Center
Email: d.maltseva@bioclinicum.com
Россия, Moscow