Target Cell Glycosylation Determines the Biodistribution of Plant Lectin Viscumin

D. V. Maltseva; V. M. Gerasimov; D. A. Sakharov; M. Yu. Shkurnikov

doi:10.1007/s10517-017-3833-8

Target Cell Glycosylation Determines the Biodistribution of Plant Lectin Viscumin

Авторлар: Maltseva D.V.¹, Gerasimov V.M.¹, Sakharov D.A.¹, Shkurnikov M.Y.¹
Мекемелер:
1. BioClinicum Research Center
Шығарылым: Том 163, № 4 (2017)
Беттер: 482-485
Бөлім: Article
URL: https://journals.rcsi.science/0007-4888/article/view/239013
DOI: https://doi.org/10.1007/s10517-017-3833-8
ID: 239013

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Аннотация

We studied the possibility of using viscumin lectin (MLI) for targeted delivery of antitumor drugs. Affinity of MLI for more than 600 oligosaccharide structures was determined and the glycosylation profiles of cell surface in various mouse tissues were analyzed. It was found that biodistribution of MLI was determined by not only expression of oligosaccharides specifically recognized by the lectin in tissue cells, but also by the structure of glycan in general.