Associations of Osteocalcin, Osteoprotegerin, and Calcitonin with Inflammation Biomarkers in Atherosclerotic Plaques of Coronary Arteries
- Авторы: Polonskaya Y.1, Kashtanova E.1, Murashov I.2, Volkov A.2, Kurguzov A.2, Chernyavsky A.2, Ragino Y.1
-
Учреждения:
- Research Institute of Internal and Preventive Medicine
- E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
- Выпуск: Том 162, № 6 (2017)
- Страницы: 726-729
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238502
- DOI: https://doi.org/10.1007/s10517-017-3698-x
- ID: 238502
Цитировать
Аннотация
We studied associations of osteocalcin, osteoprotegerin, and calcitonin with markers of inflammation in atherosclerotic plaques in coronary arteries and assessed the influence of these biomolecules on calcification of atherosclerotic plaques. The initial stage of calcification of atherosclerotic plaques is characterized by activation of inflammatory processes, which is seen from increased levels of proinflammatory biomarkers (IL-6, IL 8, TNF-α, and IL-1β). Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin. The exception is osteocalcin, its concentration significantly increased during calcification. The results suggest that severe vascular calcification can be regarded as non-specific marker of atherosclerosis. Instability of atherosclerotic plaques is associated with higher level of calcification.
Об авторах
Ya. Polonskaya
Research Institute of Internal and Preventive Medicine
Автор, ответственный за переписку.
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk
E. Kashtanova
Research Institute of Internal and Preventive Medicine
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk
I. Murashov
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk
A. Volkov
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk
A. Kurguzov
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk
A. Chernyavsky
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk
Yu. Ragino
Research Institute of Internal and Preventive Medicine
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk