Associations of Osteocalcin, Osteoprotegerin, and Calcitonin with Inflammation Biomarkers in Atherosclerotic Plaques of Coronary Arteries


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Аннотация

We studied associations of osteocalcin, osteoprotegerin, and calcitonin with markers of inflammation in atherosclerotic plaques in coronary arteries and assessed the influence of these biomolecules on calcification of atherosclerotic plaques. The initial stage of calcification of atherosclerotic plaques is characterized by activation of inflammatory processes, which is seen from increased levels of proinflammatory biomarkers (IL-6, IL 8, TNF-α, and IL-1β). Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin. The exception is osteocalcin, its concentration significantly increased during calcification. The results suggest that severe vascular calcification can be regarded as non-specific marker of atherosclerosis. Instability of atherosclerotic plaques is associated with higher level of calcification.

Об авторах

Ya. Polonskaya

Research Institute of Internal and Preventive Medicine

Автор, ответственный за переписку.
Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk

E. Kashtanova

Research Institute of Internal and Preventive Medicine

Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk

I. Murashov

E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology

Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk

A. Volkov

E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology

Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk

A. Kurguzov

E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology

Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk

A. Chernyavsky

E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology

Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk

Yu. Ragino

Research Institute of Internal and Preventive Medicine

Email: yanapolonskaya@yandex.ru
Россия, Novosibirsk


© Springer Science+Business Media New York, 2017

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