Associations of Osteocalcin, Osteoprotegerin, and Calcitonin with Inflammation Biomarkers in Atherosclerotic Plaques of Coronary Arteries
- Authors: Polonskaya Y.V.1, Kashtanova E.V.1, Murashov I.S.2, Volkov A.M.2, Kurguzov A.V.2, Chernyavsky A.M.2, Ragino Y.I.1
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Affiliations:
- Research Institute of Internal and Preventive Medicine
- E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
- Issue: Vol 162, No 6 (2017)
- Pages: 726-729
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238502
- DOI: https://doi.org/10.1007/s10517-017-3698-x
- ID: 238502
Cite item
Abstract
We studied associations of osteocalcin, osteoprotegerin, and calcitonin with markers of inflammation in atherosclerotic plaques in coronary arteries and assessed the influence of these biomolecules on calcification of atherosclerotic plaques. The initial stage of calcification of atherosclerotic plaques is characterized by activation of inflammatory processes, which is seen from increased levels of proinflammatory biomarkers (IL-6, IL 8, TNF-α, and IL-1β). Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin. The exception is osteocalcin, its concentration significantly increased during calcification. The results suggest that severe vascular calcification can be regarded as non-specific marker of atherosclerosis. Instability of atherosclerotic plaques is associated with higher level of calcification.
About the authors
Ya. V. Polonskaya
Research Institute of Internal and Preventive Medicine
Author for correspondence.
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk
E. V. Kashtanova
Research Institute of Internal and Preventive Medicine
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk
I. S. Murashov
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk
A. M. Volkov
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk
A. V. Kurguzov
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk
A. M. Chernyavsky
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine
Email: yanapolonskaya@yandex.ru
Russian Federation, Novosibirsk