Changes in the Neurochemical Composition of Motor Neurons of the Spinal Cord in Mice under Conditions of Space Flight
- Авторы: Porseva V.1, Shilkin V.1, Strelkov A.1, Krasnov I.2, Masliukov P.1
-
Учреждения:
- Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Ministry of Health of the Russian Federation
- Laboratory of Gravitational Biology, State Scientific Centre Institute of Biomedical Problems, Russian Academy of Sciences
- Выпуск: Том 162, № 3 (2017)
- Страницы: 336-339
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238178
- DOI: https://doi.org/10.1007/s10517-017-3609-1
- ID: 238178
Цитировать
Аннотация
Expression of choline acetyltransferase, 200-kDa neurofilament protein, 28-kDa calbindin, neuronal NO synthase, caspase 3, and Ki-67 in the motor neurons of spinal cord segments T3-T5 in male C57Bl/6 mice after 30-day space flight in the Bion-M1 biosatellite was studied by immunohistochemical methods. Under conditions space flight, the size of motoneurons increased, the number of neurons containing choline acetyltransferase and neurofilaments, decreased, and the number of calbindin-positive neurons increased; motoneurons, expressing neuronal NO synthase and caspase 3 appeared, while Ki-67 was not detected. Fragmentation of neurons with the formation structures similar to apoptotic (residual) bodies was observed in individual caspase 3-positive motoneurons.
Об авторах
V. Porseva
Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Email: mpm@yma.ac.ru
Россия, Yaroslavl
V. Shilkin
Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Email: mpm@yma.ac.ru
Россия, Yaroslavl
A. Strelkov
Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Email: mpm@yma.ac.ru
Россия, Yaroslavl
I. Krasnov
Laboratory of Gravitational Biology, State Scientific Centre Institute of Biomedical Problems, Russian Academy of Sciences
Email: mpm@yma.ac.ru
Россия, Moscow
P. Masliukov
Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: mpm@yma.ac.ru
Россия, Yaroslavl