Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice
- Авторы: Kolik L.1, Nadorova A.1, Seredenin S.1
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Учреждения:
- V. V. Zakusov Research Institute of Pharmacology
- Выпуск: Том 162, № 1 (2016)
- Страницы: 56-59
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237899
- DOI: https://doi.org/10.1007/s10517-016-3544-6
- ID: 237899
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Аннотация
The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the development of ethanol-induced (2.0 g/kg intraperitoneally) hyperlocomotion, in contrast to σ1-receptors agonist Afobazole (1.0 mg/kg, intraperitoneally) that did not inhibit ethanol-induced behavioral stimulation. Single dose of Selank significantly blocked manifestation of motor sensitization without affecting its formation. These findings suggest that Selank can modulate the motivational effects of ethanol.
Об авторах
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
Автор, ответственный за переписку.
Email: lgkolik@mail.ru
Россия, Moscow
A. Nadorova
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Россия, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Россия, Moscow
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