Отправить статью по E-mail Sensitivity of C6 Glioma Cells Carrying the Human Poliovirus Receptor to Oncolytic Polioviruses
- Авторы: Sosnovtseva A.1,2, Lipatova A.2, Grinenko N.3, Baklaushev V.1, Chumakov P.2, Chekhonin V.1,3
-
Учреждения:
- Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Department of Basic and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
- Выпуск: Том 161, № 6 (2016)
- Страницы: 821-825
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237814
- DOI: https://doi.org/10.1007/s10517-016-3520-1
- ID: 237814
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
A humanized line of rat C6 glioma cells expressing human poliovirus receptor was obtained and tested for the sensitivity to oncolytic effects of vaccine strains of type 1, 2, and 3 polioviruses. Presentation of the poliovirus receptor on the surface of C6 glioma cells was shown to be a necessary condition for the interaction of cells with polioviruses, but insufficient for complete poliovirus oncolysis.
Об авторах
A. Sosnovtseva
Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: aososnovtceva@gmail.com
Россия, Moscow; Moscow
A. Lipatova
Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: aososnovtceva@gmail.com
Россия, Moscow
N. Grinenko
Department of Basic and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: aososnovtceva@gmail.com
Россия, Moscow
V. Baklaushev
Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: aososnovtceva@gmail.com
Россия, Moscow
P. Chumakov
Laboratory of Cell Proliferation, V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: aososnovtceva@gmail.com
Россия, Moscow
V. Chekhonin
Department of Medical Nanobiotechnologies, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Department of Basic and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: aososnovtceva@gmail.com
Россия, Moscow; Moscow
