Nephroprotective Effect Exogenous Antioxidant Enzymes during Ischemia/Reperfusion-Induced Damage of Renal Tissue
- Авторы: Palutina O.1, Sharapov M.1, Temnov A.1, Novoselov V.1
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Учреждения:
- Institute of Cellular Biophysics, Russian Academy of Sciences
- Выпуск: Том 160, № 3 (2016)
- Страницы: 322-326
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236697
- DOI: https://doi.org/10.1007/s10517-016-3161-4
- ID: 236697
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Аннотация
Nephroprotective effect of exogenous chimeric antioxidant enzyme with combined superoxide dismutase and peroxide activities (PSH protein) was studied on the model of ischemia/reperfusion damage of the renal tissue. It was shown that post-ischemic (25- and 45-min ischemia) intravenous administration of PSH protein significantly normalized the levels of creatinine and urea. Histological studies showed that as distinct from ischemic kidney, the structure of renal corpuscles and tubules remained unchanged, the number of atrophied glomeruli and glomeruli with exudates and protein inclusions decreased in the capsular teeth after postischemic intravenous administration of PSH protein. Immunohistochemical investigations showed that post-ischemic intravenous injection of PSH protein significantly reduced the intensity of apoptosis in ischemic renal tissues.
Об авторах
O. Palutina
Institute of Cellular Biophysics, Russian Academy of Sciences
Email: novoselov-vi@rambler.ru
Россия, Pushchino, Moscow region
M. Sharapov
Institute of Cellular Biophysics, Russian Academy of Sciences
Email: novoselov-vi@rambler.ru
Россия, Pushchino, Moscow region
A. Temnov
Institute of Cellular Biophysics, Russian Academy of Sciences
Email: novoselov-vi@rambler.ru
Россия, Pushchino, Moscow region
V. Novoselov
Institute of Cellular Biophysics, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: novoselov-vi@rambler.ru
Россия, Pushchino, Moscow region
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