Effect of Glycosaminoglycans on Pathogenic Properties Far-Eastern Tick-Borne Encephalitis Virus
- Autores: Leonova G.1, Belikov S.1
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Afiliações:
- G. P. Somov Research Institute of Epidemiology and Microbiology
- Edição: Volume 167, Nº 4 (2019)
- Páginas: 482-485
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241813
- DOI: https://doi.org/10.1007/s10517-019-04555-4
- ID: 241813
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Resumo
We studied the effect of sulfated glycosaminoglycan on the infection properties of high-virulence Dal’negorsk strain and low-virulence Primorye-437 of tick-borne encephalitis virus. Differences in reproductive activity of these strains and their tropism to the target cells were revealed. Glycosaminoglycan reduced pathogenetic activity of high-virulence strain in vitro, but had no effect on low-virulence strain. The interaction of imperfect virus particles of non-pathogen strain with the glycosaminoglycan led to their accumulation in cell, but in the culture medium of SPEV cells infected with experimental and control samples, accumulation of virus particles did not differ. The results on activity of glycosaminoglycan binding with strains differing by their biological and molecular genetic characteristics can be used to assess their pathogenic potential.
Sobre autores
G. Leonova
G. P. Somov Research Institute of Epidemiology and Microbiology
Autor responsável pela correspondência
Email: galinaleon41@gmail.com
Rússia, Vladivostok
S. Belikov
G. P. Somov Research Institute of Epidemiology and Microbiology
Email: galinaleon41@gmail.com
Rússia, Vladivostok
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