Experimental Evaluation of the Properties of 3D Porous Bone Substitute Based on Calcium Phosphate on the Model of Monocortical Diaphysial Femur Defect in Rats
- Autores: Dubrov V.1, Klimashina E.2,3, Shcherbakov I.1, Shipunov G.1, Putlyaev V.2,3, Evdokimov P.2,3, Tikhonov A.2, Zyuzin D.1, Danilova N.1, Mal’kov P.1
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Afiliações:
- Faculty of Fundamental Medicine
- Faculty of Material Sciences
- Faculty of Chemistry, M. V. Lomonosov Moscow State University
- Edição: Volume 167, Nº 3 (2019)
- Páginas: 400-403
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241751
- DOI: https://doi.org/10.1007/s10517-019-04536-7
- ID: 241751
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Resumo
A new alloplastic high-permeable material based on tricalcium phosphate with Kelvin architectonics created by stereolithographic 3D-printing was studied in vivo. A monocortical defect of the femur was modeled in rats and the material was implanted into the defect area. In 24 weeks, the animals were euthanized and histological examination of the defect area was performed. One femur fracture with fixator migration was recorded after implantation of the studied material and the reference chronOS synthetic material. The studied material demonstrated better osteoconductive properties then traditional osteoplastic material, which was seen from greater number of bone trabeculae and their area in the defect area.
Sobre autores
V. Dubrov
Faculty of Fundamental Medicine
Autor responsável pela correspondência
Email: vduort@gmail.com
Rússia, Moscow
E. Klimashina
Faculty of Material Sciences; Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: vduort@gmail.com
Rússia, Moscow; Moscow
I. Shcherbakov
Faculty of Fundamental Medicine
Email: vduort@gmail.com
Rússia, Moscow
G. Shipunov
Faculty of Fundamental Medicine
Email: vduort@gmail.com
Rússia, Moscow
V. Putlyaev
Faculty of Material Sciences; Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: vduort@gmail.com
Rússia, Moscow; Moscow
P. Evdokimov
Faculty of Material Sciences; Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: vduort@gmail.com
Rússia, Moscow; Moscow
A. Tikhonov
Faculty of Material Sciences
Email: vduort@gmail.com
Rússia, Moscow
D. Zyuzin
Faculty of Fundamental Medicine
Email: vduort@gmail.com
Rússia, Moscow
N. Danilova
Faculty of Fundamental Medicine
Email: vduort@gmail.com
Rússia, Moscow
P. Mal’kov
Faculty of Fundamental Medicine
Email: vduort@gmail.com
Rússia, Moscow
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