Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress
- Autores: Samotrueva M.1, Yasenyavskaya A.1, Murtalieva V.1, Bashkina O.1, Myasoedov N.2, Andreeva L.2, Karaulov A.3
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Afiliações:
- Astrakhan State Medical University, Ministry of Health of the Russian Federation
- Institute of Molecular Genetics, Russian Academy of Sciences, Ministry of Health of the Russian Federation
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
- Edição: Volume 166, Nº 6 (2019)
- Páginas: 754-758
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241341
- DOI: https://doi.org/10.1007/s10517-019-04434-y
- ID: 241341
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Resumo
We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of “social” stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs. It was found that changes in the immune response caused by “social” stress are multidirectional, which confirms the theory of stress-induced “immune imbalance”. Semax acted as effective immune corrector restoring cellular and humoral immunogenesis reactions and phagocytic activity of neutrophils. This attested to the presence of immunomodulating properties in Semax and necessitates further studies in this field.
Sobre autores
M. Samotrueva
Astrakhan State Medical University, Ministry of Health of the Russian Federation
Email: yasen_9@mail.ru
Rússia, Astrakhan
A. Yasenyavskaya
Astrakhan State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: yasen_9@mail.ru
Rússia, Astrakhan
V. Murtalieva
Astrakhan State Medical University, Ministry of Health of the Russian Federation
Email: yasen_9@mail.ru
Rússia, Astrakhan
O. Bashkina
Astrakhan State Medical University, Ministry of Health of the Russian Federation
Email: yasen_9@mail.ru
Rússia, Astrakhan
N. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences, Ministry of Health of the Russian Federation
Email: yasen_9@mail.ru
Rússia, Moscow
L. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences, Ministry of Health of the Russian Federation
Email: yasen_9@mail.ru
Rússia, Moscow
A. Karaulov
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: yasen_9@mail.ru
Rússia, Moscow