Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing against the Background of Rheumatoid Arthritis
- Autores: Safonova О.1, Popova T.1, Shestakova T.1
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Afiliações:
- Department of Medical Biochemistry and Microbiology, Voronezh State University
- Edição: Volume 166, Nº 5 (2019)
- Páginas: 606-609
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241225
- DOI: https://doi.org/10.1007/s10517-019-04401-7
- ID: 241225
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Resumo
We studied the effect of 4-methyl-phenyl biguanide, a substance chosen by PASS software (Prediction of Activity Spectra for Substance), on oxidative status and activity of oxidation metabolism enzymes participating in limitation free radical processes (aconitate hydratase, glucose-6-phosphate dehydrogenase, and NADP-isocitrate dehydrogenase) in the heart and blood serum of rats with cardiovascular pathology developing against the background of experimental rheumatoid arthritis. Activity of cardiomyocyte cytolysis markers in rat blood serum was also measured. Normalization of the studied parameters under the influence of the test compound in animals with experimental pathology attests to its positive effects on metabolic and free radical processes.
Sobre autores
О. Safonova
Department of Medical Biochemistry and Microbiology, Voronezh State University
Autor responsável pela correspondência
Email: solya333@mail.ru
Rússia, Voronezh
T. Popova
Department of Medical Biochemistry and Microbiology, Voronezh State University
Email: solya333@mail.ru
Rússia, Voronezh
T. Shestakova
Department of Medical Biochemistry and Microbiology, Voronezh State University
Email: solya333@mail.ru
Rússia, Voronezh