Post-Weaning Social Isolation Disturbs Gene Expression in Rat Brain Structures
- Autores: Zubkov E.1, Zorkina Y.1, Orshanskaya E.2, Khlebnikova N.3, Krupina N.3, Chekhonin V.1
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Afiliações:
- Department of Basic and Applied Neurobiology, V. P. Serbsky National medical Research Center of Psychiatry and Narcology, Ministry of Health of Russian Federation
- Laboratory of General Pathology of the Cardiorespiratory System
- Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology
- Edição: Volume 166, Nº 3 (2019)
- Páginas: 364-368
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/241014
- DOI: https://doi.org/10.1007/s10517-019-04351-0
- ID: 241014
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Resumo
Post-weaning social isolation of male Wistar rats for 10 weeks led to an increase of their aggressiveness, sensorimotor reactivity, and cognitive deficiency, manifesting in training disorders evaluated by the acoustic startle response (amplitude of the response decreasing). Expression of gene encoding serine protease prolyl endopeptidase (EC 3.4.21.26) in the frontal cortex was higher than in control rats kept in groups, while the level of mRNA of the gene encoding dipeptidyl peptidase IV (EC 3.4.14.5) did not differ from the control in any of the brain structures. The levels of serotonin transporter gene mRNA in the striatum and hypothalamus were higher than in the control. No appreciable changes in the expression of genes encoding tryptophan hydroxylase-2 and monoaminoxidase A and B in the frontal cortex, striatum, amygdala, hypothalamus, and hippocampus were detected. The data indicated the involvement of genes associated with the serotoninergic system in the mechanisms of mental disorders induced by post-weaning social isolation and suggest the gene encoding prolyl endopeptidase as a candidate gene involved in the pathogenesis of these disorders.
Sobre autores
E. Zubkov
Department of Basic and Applied Neurobiology, V. P. Serbsky National medical Research Center of Psychiatry and Narcology, Ministry of Health of Russian Federation
Email: krupinana@yandex.ru
Rússia, Moscow
Ya. Zorkina
Department of Basic and Applied Neurobiology, V. P. Serbsky National medical Research Center of Psychiatry and Narcology, Ministry of Health of Russian Federation
Email: krupinana@yandex.ru
Rússia, Moscow
E. Orshanskaya
Laboratory of General Pathology of the Cardiorespiratory System
Email: krupinana@yandex.ru
Rússia, Moscow
N. Khlebnikova
Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology
Email: krupinana@yandex.ru
Rússia, Moscow
N. Krupina
Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology
Autor responsável pela correspondência
Email: krupinana@yandex.ru
Rússia, Moscow
V. Chekhonin
Department of Basic and Applied Neurobiology, V. P. Serbsky National medical Research Center of Psychiatry and Narcology, Ministry of Health of Russian Federation
Email: krupinana@yandex.ru
Rússia, Moscow