Immunohistochemical Phenotypes of Stable and Unstable Occlusive Atherosclerotic Plaques in Coronary Arteries
- Autores: Murashov I.1,2, Volkov A.2, Kazanskaya G.2, Kliver E.2, Savchenko S.3, Klochkova S.1, Lushnikova E.1
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Afiliações:
- Institute of Molecular Pathology and Pathophysiology, Federal Research Center of Fundamental and Translational Medicine
- E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 165, Nº 6 (2018)
- Páginas: 798-802
- Seção: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/240755
- DOI: https://doi.org/10.1007/s10517-018-4268-6
- ID: 240755
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Resumo
We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphometric and immunohistochemical methods. The expression of MMP-2 and MMP-9 as well as the intensity of neoangiogenesis estimated by the expression of CD31, CD34, and factor VIII in unstable plaques was significantly higher than in stable ones. Immunohistochemical analysis showed more intensive collagen IV expression in stable plaques. The observed differences in immunohistochemical phenotypes of stable and unstable atherosclerotic plaques reflect peculiarities of morphogenesis of atherosclerotic foci in the coronary arteries determining their further development.
Sobre autores
I. Murashov
Institute of Molecular Pathology and Pathophysiology, Federal Research Center of Fundamental and Translational Medicine; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: pathol@inbox.ru
Rússia, Novosibirsk; Novosibirsk
A. Volkov
E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
Rússia, Novosibirsk
G. Kazanskaya
E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
Rússia, Novosibirsk
E. Kliver
E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
Rússia, Novosibirsk
S. Savchenko
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
Rússia, Novosibirsk
S. Klochkova
Institute of Molecular Pathology and Pathophysiology, Federal Research Center of Fundamental and Translational Medicine
Email: pathol@inbox.ru
Rússia, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathophysiology, Federal Research Center of Fundamental and Translational Medicine
Email: pathol@inbox.ru
Rússia, Novosibirsk