Quantitative Analysis of Red Bone Marrow Microenvironment Cells in Patients with Chronic Myeloid Leukemia, Multiple Myeloma, and Chronic Lymphocytic Leukemia in the Dynamics of Chemotherapy
- Autores: Dolgikh T.1, Kachesov I.1, Tornuev V.1, Vinogradova E.1, Krinitsyna Y.1
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Afiliações:
- Institute of Molecular Pathology and Pathomorphology
- Edição: Volume 165, Nº 6 (2018)
- Páginas: 786-789
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/240751
- DOI: https://doi.org/10.1007/s10517-018-4265-9
- ID: 240751
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Resumo
We performed comparative analysis of quantitative changes in the populations of bone marrow microenvironment cells in patients with chronic myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia in the debut, during response to chemotherapy, and during relapse/progression/loss of response. It was shown that in the active phase of hemoblastoses, the number of reticular cells and fibroblasts in trephine biopsy specimens was higher than in the phase of response to chemotherapy and than in the control group. In patients with relapse of multiple myeloma and loss of response in chronic myeloid leukemia, the percentage ratio of adipocytes in the bone marrow significantly (by 9-13-fold) increased. In addition, endotheliocytes appear in the active phase of all hemoblastoses in trephine biopsy specimens, while in the phase of response to chemotherapy and in the control group, these cells were absent. The revealed quantitative changes in bone marrow stromal cells can be taken into account during assessing the phase of hemoblastosis and effectiveness of chemotherapy.
Sobre autores
T. Dolgikh
Institute of Molecular Pathology and Pathomorphology
Autor responsável pela correspondência
Email: pathol@soramn.ru
Rússia, Novosibirsk
I. Kachesov
Institute of Molecular Pathology and Pathomorphology
Email: pathol@soramn.ru
Rússia, Novosibirsk
V. Tornuev
Institute of Molecular Pathology and Pathomorphology
Email: pathol@soramn.ru
Rússia, Novosibirsk
E. Vinogradova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@soramn.ru
Rússia, Novosibirsk
Yu. Krinitsyna
Institute of Molecular Pathology and Pathomorphology
Email: pathol@soramn.ru
Rússia, Novosibirsk
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